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Prague-Ruzyne Airport (PRG):
Approximate driving time is 25 minutes
Approximate distance is 13 miles or 20 kilometers.
From Prague-Ruzyne Airport:
Follow signs for "Praha Centrum".
Follow signs "Historic Centrum/Old Castle/Mala Strana district".
Once you have reached the Mala Strana Square,
Take the Mostecka Street until the St Nicholas Street.
The Nerudova Street is the first street on your left.
It is just behind the main gate of the Prague Castle.